Effects of Gum Arabic and its nanoparticles on hepato-renal toxicity induced by bromobenzene in male rats: Physiological, histological, and immunological studies

This experimental study investigates the possible protective effects of Gum Arabic (GA) and its nanoparticles in hepato- reno-toxicity induced by bromobenzene (BB) rats mechanisms action. Thirty-five adult male albino were sorted into following: Group 1 (control), 2 (NPs), 3 (GA, received ml/kg 10%w/v aqueous suspension), 4 (Gum-NPs, GA loaded NPs), 5 (BB), 460 mg/kg, 6 (GA+BB) 7 (GA-NPs+BB). Treatment was via oral gavage daily for 10 days. Liver kidney functions measured sera total antioxidant capacity (TAC) tissue homogenates, renal hepatic tissues expression caspase-3 immuno-histochemical assessed beside histological alteration using a light microscope. BB treatment produced impairment liver decreased TAC activities increased expressions altered structures. Co-administration on NPs days alleviated damaged BB, especially GA-NPs groups structures, decrease tissues. In conclusion, had actions versus BB-induced destruction due to antioxidant, anti-inflammatory anti-apoptosis actions.